Before joining BYU, Dr. Payne was an Senior Research Scientist at the Pacific Northwest National Laboratory and an Assistant Professor of Informatics at the J. Craig Venter Institute. Dr. Payne received a B.S. of computer science at Brigham Young University. He earned his Ph.D. in Bioinformatics from UC, San Diego working with Dr. Vineet Bafna.
Dr. Payne's research interests are focused on algorithms for proteomics data analysis and subsequent interpretation and integration. He is PI of a cancer informatics proposal through the National Cancer Institute in collaboration with NYU and Washington University (WUSTL). As part of NCI's CPTAC consortium, Dr. Payne's group is involved in the analysis of large clinical cohorts for Ovarian, Endometrial, Glioblastoma and other cancers. The lab's current focus is on the effects of DNA mutations on protein abundance and activity.
Kushner IK, Clair G, Purvine SO, Lee JY, Adkins JN, Payne SH (2018) Individual Variability of Protein Expression in Human Tissues. J Proteome Res 17(11):3914-3922. doi: 10.1021/acs.jproteome.8b00580.
Sengupta S, Sun SQ, Huang KL, Oh C, Bailey MH, Varghese R, Wyczalkowski MA, Ning J, Tripathi P, McMichael JF, Johnson KJ, Kandoth C, Welch J, Ma C, Wendl MC, Payne SH, Fenyö D, Townsend RR, Dipersio JF, Chen F, Ding L (2018) Integrative omics analyses broaden treatment targets in human cancer. Genome Med. 10(1):60. doi: 10.1186/s13073-018-0564-z.
Lee JY, Fujimoto GM, Wilson R, Wiley HS, Payne SH (2017) Blazing Signature Filter: a library for fast pairwise similarity comparisons. BMC Bioinformatics. 19(1):221. doi: 10.1186/s12859-018-2210-6.
Hosseini MM, Kurtz SE, Abdelhamed S, Mahmood S, Davare MA, Kaempf A, Elferich J, McDermott JE, Liu T, Payne SH, Shinde U, Rodland KD, Mori M, Druker BJ, Singer JW, Agarwal A. (2018) Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes. Leukemia. doi: 10.1038/s41375-018-0112-2.
Jayasinghe RG, Cao S, Gao Q, Wendl MC, Vo NS, Reynolds SM, Zhao Y, Climente-González H, Chai S, Wang F, Varghese R, Huang M, Liang WW, Wyczalkowski MA, Sengupta S, Li Z, Payne SH, Fenyö D, Miner JH, Walter MJ; Cancer Genome Atlas Research Network, Vincent B, Eyras E, Chen K, Shmulevich I, Chen F, Ding L. (2018) Systematic Analysis of Splice-Site-Creating Mutations in Cancer. Cell Rep. 23(1):270-281.e3. doi: 10.1016/j.celrep.2018.03.052.
Zhang H, Liu T, Zhang Z, Payne SH, Zhang B, McDermott JE, Zhou JY, Petyuk VA, Chen L, Ray D, Sun S, Yang F, Chen L, Wang J, Shah P, Cha SW, Aiyetan P, Woo S, Tian Y, Gritsenko MA, Clauss TR, Choi C, Monroe ME, Thomas S, Nie S, Wu C, Moore RJ, Yu KH, Tabb DL, Fenyö D, Bafna V, Wang Y, Rodriguez H, Boja ES, Hiltke T, Rivers RC, Sokoll L, Zhu H, Shih IM, Cope L, Pandey A, Zhang B, Snyder MP, Levine DA, Smith RD, Chan DW, Rodland KD. (2016) Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer. Cell 166:755-765. doi: 10.1016/j.cell.2016.05.069.
Payne SH. (2015) The utility of protein and mRNA correlation. Trends Biochem Sci. 40:1-3. doi: 10.1016/j.tibs.2014.10.010